New York Yankees vs Boston Red Sox Prediction, Odds and Picks for Today, 09/12/25

The Boston Red Sox and New York Yankees open a pivotal 3-game series at Fenway as both teams look to chip away at the Blue Jays lead in the AL East. The Yankees have struggled against Boston this season, with Boston taking 8 of the first 10 games. The Red Sox will look to keep that momentum going behind Lucas Giolito, who enters with a 10-3 record and a 3.38 ERA. 

For the Yankees, Luis Gil gets the start, entering with a 3-1 record and a 3.31 ERA. The last time Gil faced the Red Sox, he allowed just 1 earned run on 4 hits in 5 innings pitched. As for Giolito, he struggled against the Yankees back on August 21 where he allowed 3 earned runs on 5 hits in 4.2 innings pitched. The Yankees are averaging 4.4 runs per game in their last 10, slightly behind the Red Sox 5.3. The Red Sox are 44-28 at home this season while the Yankees are 37-34 on the road. With lingering questions around New York’s bullpen, Boston will look to take advantage of their recent struggles in tonight’s matchup. The Red Sox have been the hotter team, and they’ll be in a good position to pick up a win tonight in front of their home crowd. 

Yankees vs Red Sox prediction: Red Sox ML (+105) available at time of publishing. Playable at that number.

Bet like a Caesar with this AMAZING new customer offer from Caesars Sportsbook. If you bet just $1, you’ll receive DOUBLE YOUR WINNINGS on your next 20 bets! Become a Caesars member 👥 using the Caesars promo code PWCONTENT20X, where you can bet on our Yankees vs Red Sox picks.