HomeMLBMLB PredictionsNew York Yankees vs Cleveland Guardians Prediction, Odds and Picks

New York Yankees vs Cleveland Guardians Prediction, Odds and Picks for Monday, 04/21/25

Updated: 6:00 AM ET Apr 22, 2025

Progressive FieldGuardians TV

14-8

Yankees

6:10 PM ETMon Apr 21

12-9

Guardians

Connor Grootenhuis

Updated: 6:00 AM ET April 22, 2025

Show Bio

Connor has been covering the sports betting industry in a wide variety of roles for almost five years, and most enjoys writing about MLB, NHL, and college football. He is an avid supporter of #MACtion, and his favorite professional teams are the Detroit Tigers and Detroit Red Wings. When it comes to his sports bets, Connor is a firm believer that every loss is a bad beat and every win is easy money.

MLB Analysis

See All MLB News

Chicago Cubs starting pitcher Jameson Taillon (50) walks to the dugout after being pulled in the third inning against the Philadelphia Phillies at Citizens Bank Park. The Phillies won 12-3.

MLB Divisional Series Wednesday YRFI/NRFI Picks & Best Bets for October 8 - Scoreless start in Cubs vs Brewers

Wednesday's slate of MLB postseason action is loaded with 4 massive games. That is 36 innings of must-see baseball, but this article focuses on just the first inning of those games. Let's dive into o...

MLBPosted 8 hours ago

MLB Division Series Predictions for Wednesday: ALDS & NLDS picks including Blue Jays vs Yankees & Phillies vs Dodgers Best Bets

MLBPosted 14 hours ago

New York Yankees right fielder Aaron Judge (99) returns to the dugout during the game against the Los Angeles Dodgers at Dodger Stadium.

MLB Divisional Series Monday YRFI/NRFI Picks & Best Bets for October 7 - Quick start to Blue Jays vs Yankees

MLBPosted 1 day ago

American League first baseman Vladimir Guerrero Jr. of the Toronto Blue Jays (27) poses for a photo as he kisses the 2021 MLB All Star Game MVP award after their 5-2 win over the National League in the 2022 MLB All-Star Game.

MLB Division Series Predictions for Tuesday: ALDS Game 3 picks including Blue Jays vs Yankees & Mariners vs Tigers

MLBPosted 1 day ago

New York Yankees vs Cleveland Guardians Prediction, Odds and Picks for Monday, 04/21/25

Connor Grootenhuis

MLB Analysis

MLB Divisional Series Wednesday YRFI/NRFI Picks & Best Bets for October 8 - Scoreless start in Cubs vs Brewers

MLB Division Series Predictions for Wednesday: ALDS & NLDS picks including Blue Jays vs Yankees & Phillies vs Dodgers Best Bets

MLB Divisional Series Monday YRFI/NRFI Picks & Best Bets for October 7 - Quick start to Blue Jays vs Yankees

MLB Division Series Predictions for Tuesday: ALDS Game 3 picks including Blue Jays vs Yankees & Mariners vs Tigers

Sport Picks

Sport Predictions

Bet Calculator

Sportsbook Promo & Bonus Codes

How To Bet Guides