New York Yankees vs Houston Astros Prediction, Odds and Picks for Today, 09/04/25

The New York Yankees will wrap up their 3-game series against the Houston Astros tonight, and we’ve got your prediction right here! The one thing the Yankees fans shouldn’t have to worry about in this matchup is seeing Devin Williams, or at least they hope so. Williams ended up surrendering 4 runs on 1 hit in just 0.2 innings pitched last night, costing New York yet another game. 

Carlos Rodon gets the start for the Yankees, entering with a 15-7 record and 3.18 ERA. Rodon appears to have found his groove, going 4-0 with a 2.19 ERA over his last 4 starts. For the Astros, Cristian Javier will get the nod, entering with a 1-1 record and 3.38 ERA. The Yankees offense has been on fire, averaging 7.4 runs per game in their last 10 compared to the Astros 3.1. New York definitely has the advantage at the plate, and they also have the advantage on the mound with Rodon. Sure, Rodon has performed terrific in his last couple of starts, but more importantly, it’s worth to note he’s 4-0 with a 2.51 ERA through 11 starts against the Astros in his career. I don’t think tonight will be the night Rodon picks up his first career loss against the Astros, as the Yankees will find a way to get it done and pick up another series win. 

Yankees vs Astros prediction: Yankees ML (-140) available at time of publishing. Playable at that number.

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