New York Yankees vs Toronto Blue Jays Prediction, Odds and Picks for Tuesday, 07/22/25

Things didn’t go as planned for the Yankees last night, but today they look to bounce back and put an end to Toronto’s 11-game home winning streak. Rookie Cameron Schlittler will take the mound for New York, making his second start of the season. He enters the matchup with a 1-0 record and a 5.06 ERA. Max Scherzer will take the mound for the Blue Jays with a record of 1-0 and a 4.70 ERA. 

The Yankees boast one of the most talented lineups in all of baseball, and they’re always worth a look, but lately, they’ve been tough to trust. Over their last 24 games, New York owns a 5.12 team ERA, compared to Toronto’s 3.69. Offensively, the Blue Jays are averaging 5.6 runs per game — just ahead of the Yankees, who sit at 5.4. Max Scherzer has struggled against the Yankees in his career, going 4-5 with a 4.21 ERA. Even though Schlittler did pick up a win in his debut, it’s hard to gauge how he will perform on a big stage like this against a tough Blue Jays team. With the Yankees’ pitching remaining a concern and their bats having a solid track record against Scherzer, I’m going to be backing the over in tonight’s matchup, as it’s too risky to trust New York.

Yankees vs Blue Jays prediction: Over 9 (-110) available at time of publishing. Playable at that number.

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