Pittsburgh Pirates vs St. Louis Cardinals Prediction, Odds and Picks for Today, 08/26/25

Prior to last night’s meeting, the last time these teams saw each other resulted in a Pirates sweep in which the Cardinals didn’t score a single run over 3 games. The Cardinals have revenge on their minds, and they started the series on the right foot with a 7-6 win on Monday night. Andre Pallante hasn’t been given much run support in recent starts, but that could change as the Cardinals go up against Pittsburgh starter Mitch Keller. August has not been kind to Keller, who owns a 9.00 ERA and .359 BAA through 4 starts so far this month. The Pirates are 2-2 in those 4 games, but as Keller continues to put his team in a difficult position, the Cardinals could have the advantage offensively.

The Pirates have been an extremely streaky team in the second half. So far in August, Pittsburgh dropped 7 of 8 games from Aug. 9-17 before winning 5 of 7 from Aug. 18-25. They dropped the series opener last night, and could have a tough time finding the win column in Tuesday’s matchup with Keller on the mound. Playing at home, look for the Cardinals to pickup a second consecutive win over the Pirates in this one.

Pirates vs Cardinals prediction: Cardinals ML (-130) available at time of publishing. Playable at that number.