San Diego Padres vs Colorado Rockies Prediction, Odds and Picks for Today, 09/07/25

The Padres and Rockies have split the first 2 games of this series, making way for a rubber match on Sunday afternoon at Coors Field. San Diego’s Dylan Cease is having the worst season of his career, and pitching on the road has been an issue all season long. The veteran right-hander has an ERA that jumps from 3.89 at home to 5.81 on the road. Now he has to pitch in the hitter-friendly Coors Field. In a small sample size, he owns a 4.15 ERA in 3 career starts at Coors. Despite the loss on Friday night, the Rockies still plated 8 runs on 14 hits, and should be able to give Cease some trouble in this one.

Colorado starting pitcher Tanner Gordon has been solid over his last few outings, but he still brings a 6.07 ERA and 1.58 WHIP into this matchup. Consistency has been an issue for the 27-year-old right-hander, and after scoring 10 runs last night, San Diego is capable of having success at the plate once again. Even with a high total, look to the over.

Padres vs Rockies prediction: Over 11.5 (-110) available at time of publishing. Playable at that number.