San Diego Padres vs Philadelphia Phillies Prediction, Odds and Game 2 Picks for Wednesday, 07/02/25

Game 2 of Wednesday’s doubleheader between the Padres and Phillies will pit San Diego’s Dylan Cease against Philadelphia’s Cristopher Sanchez. Cease has struggled away from Petco Park, as his ERA jumps from 2.76 at home to 6.31 on the road. In addition, his BAA goes from .223 to .264. He could have his hands full with a Philadelphia lineup that thrives in their home ballpark. The Phillies own a team OPS of .780 when playing at home, which ranks sixth in all of baseball. Cease had an up-and-down month of June, and his road struggles are a bit worrisome as he goes up against a tough Philadelphia lineup.

On the other side, Sanchez was outstanding in the month of June. In 5 starts and 34 innings, he posted an ERA of 1.85 and racked up 33 strikeouts while walking just 6. The Padres don’t hit lefties well, and with the way Sanchez is pitching right now, San Diego could be in for a long night at the plate. The Padres struggled at the plate in June, as their .679 OPS ranked 25th in baseball. Look for the Phillies to find the win column in Game 2 tonight.

Padres vs Phillies prediction: Phillies ML (-155) available at time of publishing. Playable to -160.