San Diego Padres vs Seattle Mariners Prediction, Odds and Picks for Monday, 08/25/25

The San Diego Padres hand the ball to JP Sears, recently acquired from the A’s in the Mason Miller trade. Sears has struggled to find consistency in 2025, carrying a 7–9 record with a 4.95 ERA and 1.27 WHIP across 22 starts. His Padres debut highlighted those issues, as he was tagged for five runs on 10 hits over five innings in a loss, which led to a brief demotion back to Triple-A. The start after was a lot better allowing just one run to the Giants. Still, Sears brings a solid pitch mix, and San Diego will look for him to settle in and provide length against a dangerous Seattle lineup. On the offensive side, the Padres have weapons that can make up for shaky pitching. Fernando Tatis Jr. continues to pace the lineup with power, while Jake Cronenworth and Xander Bogaerts have been steady run producers. Against a starter still working his way back into rhythm, this lineup has the potential to break through early and often.

The Seattle Mariners counter with Bryce Miller, who has had a rocky 2025 season of his own, posting a 2–5 record with a 5.87 ERA, 1.51 WHIP, and 43 strikeouts in 53.2 innings. Miller possesses a lively fastball and an intriguing mix of off speed pitches, but his command and hard hit rates have been problematic, often putting him in early trouble. The Mariners’ bullpen has helped mask some of those issues, but against San Diego’s power bats, Miller will need to be sharp from the first pitch. Seattle’s offense, led by Julio Rodríguez and Cal Raleigh, has provided flashes of support, but inconsistencies remain. With both starting pitchers carrying question marks and the Padres’ offense showing signs of heating up, the edge lies with San Diego to push across runs against Miller. The best angle here is the Padres Team Total Over 3.5, as four or more runs from this lineup feels well within reach.

Padres vs Mariners Prediction: Padres TT Over 3.5 (-130) available at time of publishing. Playable to -140