San Diego Padres vs Seattle Mariners Prediction, Odds and Picks for Today, 08/26/25

In this game, we will see the San Diego Padres take on the Seattle Mariners. The Padres are fighting for 1^st place in their division while the Mariners are fighting for a wild card spot. On the mound today, we have Dylan Cease of the Padres and Luis Castillo of the Mariners. Both pitchers have been struggling, with Cease giving up 7 runs in his last 2 starts and Castillo giving up 9 runs in his last 2 starts. Where these 2 differ is in their splits on the season. In away games, Cease has a 5.65 ERA giving up 64 hits and 41 runs in 65.1 innings. Cease also holds a record of 0-8 in away games this season. Castillo on the other hand, has a 2.41 home ERA giving up 61 hits and 22 runs through 82 innings pitched. With numbers like this, the location of this game makes a world of a difference.

Outside of the starting pitchers, the Padres hold the edge in hitting statistics on the season. What is surprising, is that the Mariners hold the worst home batting average in the MLB (.223) but have a home record of 40-26. These numbers show how impressive their pitching is at T-Mobile Park. Speaking of pitching, we saw the Padres bullpen give up 6 runs in the final game with the Los Angeles Dodgers and 5 runs again last night. These bullpen struggles are not common in San Diego, but I have no reason to believe they will stop today. Overall, I suspect that the Mariners pitching will be too much for the Padres to handle. I am taking the Mariners to get the win.

Padres vs. Mariners Prediction: Mariners ML (-115) available at the time of publishing. Playable at that number.