San Francisco Giants vs Arizona Diamondbacks Prediction, Odds and Picks for Today, 09/16/25

The San Francisco Giants are expected to hand the ball to Tristan Beck, who has mostly worked in relief this season but is being stretched into a starting role. Beck has posted a 4.88 ERA with 36 strikeouts over 48 innings, but most of his work has come in short stints, and he hasn’t been asked to turn over a lineup multiple times very often. That raises questions about his ability to handle a deeper workload against a Diamondbacks lineup that has been steadily improving down the stretch. Arizona’s offense has been sparked by contributions from the likes of Geraldo Perdomo headlining the lineup, giving them enough balance to pressure pitchers who struggle with command or fatigue early. If Beck falters, San Francisco will be forced to lean heavily on its bullpen, which has already logged significant innings this year.

The Arizona Diamondbacks counter with Eduardo Rodriguez, who brings more experience and steadier production to the matchup. Though his season line of 8-8 with a 4.98 ERA and 1.55 WHIP doesn’t stand out, Rodríguez has shown improved form lately, limiting runs and displaying better control in recent outings. When he’s locating his fastball and mixing in his changeup effectively, he can navigate lineups and set up the bullpen in favorable situations. With the Giants relying on a makeshift starter and the Diamondbacks showing more offensive depth and consistency, Arizona holds the edge on both the mound and at the plate. Backed by Rodriguez’s recent stability and a lineup capable of creating traffic on the bases, the Diamondbacks ML looks like the stronger play in this matchup.

Giants vs DBacks Prediction: DBacks ML (-130) available at time of publishing. Playable to -140