San Francisco Giants vs Arizona Diamondbacks Prediction, Odds and Picks for Today, 09/17/25

The San Francisco Giants and Arizona Diamondbacks finish a series on Wednesday afternoon, and this series has become an unexpected battleground for the NL wild card. Both teams are trying to chase down the Mets, and the D-Backs have now climbed over both the Giants and Reds to put themselves in the hunt. For the Giants, Wednesday is awfully close to a do-or-die game, and I like them to salvage a win in the series after Arizona walked off a 6-5 win on Tuesday. My Giants vs Diamondbacks pick is the Giants on the Money Line.

For sure, I love the SF pitching situation far better. Justin Verlander has been terrific over his past 4 starts, thumbing his nose at Father Time while allowing only 3 runs in the past 24 innings. He is also backed by one of the league’s best bullpens when he leaves. Arizona will roll the dice with Brandon Pfaadt, and a roll of the dice it is with him every time out. Pfaadt has been blown up a ton of times this season, and only once in his last 4 starts has he escaped the 5^th inning or allowed fewer than 4 runs. And whenever he leaves the game, he is followed by a D-Backs bullpen that has been a liability all season long. Arizona is clearly the superior lineup, but it is hard to look past this pitching advantage for the Giants. Give me SF to win.

Giants vs Diamondbacks Prediction: Giants ML (-110) available at the time of publishing. Playable at that number.