San Francisco Giants vs Chicago Cubs Prediction, Odds and Picks for Tuesday, 05/06/25
Vote on who will win!
Best Bets
The San Francisco Giants face off against the Chicago Cubs for the second game of the series. On Monday the Cubs won won 9-2, doing their damage with 9 hits and 4 errors by the Giants. On the mound today are San Francisco’s Justin Verlander and Chicago’s Colin Rea. Verlander has struggled to start the year with a 4.38 ERA. He has turned it on in recent starts, but those were against some of the worst hitting teams in the MLB. On the other side, Rea is off to a wonderful start. He currently boasts a 0.77 ERA at home while pitching 11.2 innings giving up 1 run on 8 hits.
On the hitting side, the Giants have scored 166 runs on 273 hits; the Cubs have scored 217 runs on 332 hits. Looking at the Giants in away games, they have a batting average of .210 — putting them at 29th in MLB. The Cubs, on the other hand, have scored 97 runs in 17 games at home. In addition to the home and away hitting statistics, the Giants are 2-5 when Verlander starts and the Cubs are 4-0 when Rea toes the rubber. Finally, San Fran has lost 6 of its last 7 away from home and Chicago has won 4 of its last 5 overall. Let’s feel good about siding with the Cubs to win this second meeting.
Giants vs Cubs prediction: Cubs ML (-150) available at time of publishing. Playable at that number.
If you’re looking for a new sportsbook, check out Bet365, the world’s #1 sportsbook. They have an amazing sign-up offer where you can INSTANTLY receive $150 in bonus bets from a $5 wager, regardless of whether that bet wins or loses! There’s no catch, it’s really that simple. Join Bet365 right now ⏰ in time to fade or follow our experts’ Giants vs Cubs predictions.
Mark Hamilton
Featured In
The Giants have won 4 of their last 5 matchups against NL Central teams.
It has been 3 games since the Giants last failed to cover the run line.
The Over is 7-3 in the Cubs' last 10 home games.
$250
Bet $50, Get $250 In Bonus Bets
Sign up for a new Fanatics Sportsbook account.
Bet $10 on any event for 5 straight days
You\'ll get $50 in bonuses each day ($250 total)
Must be 21+ to participate. | T&Cs apply. | Play Responsibly. | Gambling problem? Call 1-800-522-4700; AZ 1-800-NEXT-STEP; CT (888) 789-7777; MA (800)-327-5050; NY 877-8-HOPENY or text HOPENY (467369); VA 1-888-532-3500; CO, IA, KS, KY, MD, NJ, OH, PA, TN, VT, WV 1-800-GAMBLER; MD Please play responsibly, for help visit mdgamblinghelp.org or call 1-800-GAMBLER
$250
Bet $50, Get $250 in Bonus Bets
Sign up for a new Fanatics Sportsbook account.
Bet $10 on any event for 5 straight days
Each days, you'll get $50 in bonuses ($250 total)
Must be 21+ to participate. | T&Cs apply. | Play Responsibly. | Gambling problem? Call 1-800-522-4700; AZ 1-800-NEXT-STEP; CT (888) 789-7777; MA (800)-327-5050; NY 877-8-HOPENY or text HOPENY (467369); VA 1-888-532-3500; CO, IA, KS, KY, MD, NJ, OH, PA, TN, VT, WV 1-800-GAMBLER; MD Please play responsibly, for help visit mdgamblinghelp.org or call 1-800-GAMBLER
$250
Bet $50, Get $250 in Bonus Bets
Sign up for a new Fanatics Sportsbook account.
Bet $10 on any event for 5 straight days
Each day, you'll win $50 in Bonus Bets ($250 total)
Must be 21+ to participate. | T&Cs apply. | Play Responsibly. | Gambling problem? Call 1-800-522-4700; AZ 1-800-NEXT-STEP; CT (888) 789-7777; MA (800)-327-5050; NY 877-8-HOPENY or text HOPENY (467369); VA 1-888-532-3500; CO, IA, KS, KY, MD, NJ, OH, PA, TN, VT, WV 1-800-GAMBLER; MD Please play responsibly, for help visit mdgamblinghelp.org or call 1-800-GAMBLER
3,600
1.1 Million Gold Coins + FREE 3,600 Sweeps Coins
Sign up for a new Funrize account
You\'ll get 1.1 million gold coins + 3,600 sweeps coins for just $19.99
Terms and Conditions apply. 18+ to play.
3,600
1.1 Million Gold Coins + FREE 3,600 Sweeps Coins
Sign up for a new Funrize account
You'll get 1.1 million gold coins + 3,600 sweeps coins for just $19.99
Terms and Conditions apply. 18+ to play.
$200
Bet $5, Get $200 Instantly!
Sign up for a new account with DraftKings Sportsbook and make your first deposit
Bet $5 on any sports market and get $200 instantly
Gambling Problem? Call 877-8-HOPENY/text HOPENY (467369) (NY), If you or someone you know has a gambling problem, crisis counseling and referral services can be accessed by calling 1-800-GAMBLER (1-800-426-2537) (CO/IL/IN/LA/MD/MI/NJ/PA/TN/WV/WY), 1-800-NEXT STEP (AZ), 1-800-522-4700 (KS), 888-789-7777/visit ccpg.org (CT), 1-800-BETS OFF (IA), or 1-888-532-3500 (VA). 21+ (18+ WY). Physically present in AZ/CO/CT/IL/IN/IA/KS/LA(select parishes)/MD/MI/NJ/NY/PA/TN/VA/WV/WY only. Void in OH/ONT. Eligibility restrictions apply. Valid 1 per new customer. Min. $5 deposit. Min. $5 bet. $200 issued as bonus bets that expire 7 days (168 hours) after being awarded. See terms at sportsbook.draftkings.com.
$200
Bet $5, Get $200 Instantly!
Sign up for a new account with DraftKings Sportsbook and make your first deposit
Bet $5 on any sports market and get $200 in bonus bets instantly
Must be 21+. Gambling Problem? If you or someone you know has a gambling problem, crisis counseling and referral services can be accessed by calling 1-800-GAMBLER (1-800-426-2537). See terms at sportsbook.draftkings.com.
Coins
Get up to 1,570,000 Gold Coins + 45 FREE Sweeps Coins upon signup
Sign up for an account with Sportzino
You’ll get a 1,570,000 Gold Coins + 45 free Sweeps Coins upon signup
Start making bets with the at the Sportzino Social Sportsbook & Casino
Get up to 1,570,000 Gold Coins + 45 FREE Sweeps Coins upon signup
Coins
Get up to 1,570,000 Gold Coins + 45 FREE Sweeps Coins upon signup
Sign up for an account with Sportzino
You’ll get a 1,570,000 Gold Coins + 45 free Sweeps Coins upon signup
Start making bets with the at the Sportzino Social Sportsbook & Casino
Get up to 1,570,000 Gold Coins + 45 FREE Sweeps Coins upon signup
COINS
Sign up to get 15,000 Gold Coins + 2.5 free Sweepstakes Coins
Sign up for a new Hello Millions casino account
Sign up to get 15,000 Gold Coins + 2.5 free Sweepstakes Coins
First-purchase bonus: 230,000 GC + 115 SC for $69.97 over first three purchases
Available to players aged 18 and up only. Gambling problem? Call 1-800-GAMBLER.
COINS
No Deposit Bonus: 5,000 Gold Coins + 2.3 Sweeps Coins!
Sign up for a new Pulsz casino account
Get 5,000 free GCs and 2.3 SCs simply by registering using code PW01
Get 362,000 GC and 30 Pulsz with a purchase of $19.99
Available to players aged 18 and up only. Gambling problem? Call 1-800-GAMBLER.
COINS
Sign up to get 7,500 Gold Coins + 2.5 free Sweepstakes Coins!
Sign up for a new McLuck casino account
Get 7,500 Gold Coins + 2.5 free Sweepstakes Coins when you sign up
150% extra coins: GC 50,000 + SC 25 FREE for $9.99
Available to players aged 18 and up only. Gambling problem? Call 1-800-GAMBLER.
MLB Analysis
See All MLB News
MLB Picks & Predictions for Wednesday, May 7: San Diego Padres vs New York Yankees and Cincinnati Reds vs Atlanta Braves
The week in Major League Baseball continues with a full 15-game schedule on Wednesday. I’m on an absolute heater in the early stages of the season, with a 22-11-1 record so far in this best bets pie...
