San Francisco Giants vs Colorado Rockies Prediction, Odds and Picks for Wednesday, 09/03/25

The San Francisco Giants enter this matchup with confidence behind ace Robbie Ray, who has re-established himself as one of the National League’s most reliable starters. Across 164 innings this season, Ray holds a strong 3.18 ERA, 1.16 WHIP, and has piled up 163 strikeouts, keeping hitters uncomfortable with his swing and miss profile. Against Rockies bats specifically, Ray has historically fared well, limiting power and forcing weak contact. That’s a critical strength at Coors Field, where pitchers often struggle to keep the ball in the yard. San Francisco’s lineup also provides early run support, with bats like Matt Chapman setting the tone at the top while Rafael Devers and Willy Adames supply power in the middle. If the Giants can string together early offense while Ray quiets the Colorado order, they are positioned to take control quickly.

For the Colorado Rockies, German Marquez takes the mound still searching for consistency after a rocky 2025 campaign. The veteran right hander has posted a 5.67 ERA and 1.64 WHIP across 98.1 innings, with home runs and command lapses continuing to plague him. Even during some of his better stretches, Marquez has struggled to avoid the big inning, which has especially hurt him at Coors Field where mistakes get magnified. Colorado’s offense has shown flashes, with Ryan McMahon and Nolan Jones capable of carrying the load, but the lineup has too often been neutralized by top tier pitching. Facing Ray in his current form, the Rockies could find themselves in an early hole once again. With Marquez’s volatility and the Giants’ ability to pressure him quickly, the edge lies with San Francisco controlling the first half of this game.

Giants vs Rockies Prediction: Giants F5 -0.5 (-150) available at time of publishing. Playable to -160

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