San Francisco Giants vs Los Angeles Dodgers Prediction, Odds and Picks for Today, 09/18/25

The San Francisco Giants face the Los Angeles Dodgers on Thursday. This looks like a fantastic pitching matchup between Logan Webb of the Giants and Yoshinobu Yamamoto of the Dodgers. Webb has been great this year to the tune of a 3.34 ERA and a 14-10 record. He struggled in his last start, against the Dodgers, in which he gave up 10 hits and 6 runs in just 4.0 innings. While this may seem like a one-off for Webb, he has struggled against the Dodgers this season. He has pitched 16.1 innings against them, giving up 18 hits and 14 earned runs. These numbers get even more intimidating when we consider that the Dodgers are batting .300 over the last 6 games while scoring 40 total runs. I have a feeling it could be a short day for Webb.

On the Dodgers’ side, Yamamoto Yamamoto is coming into this one after 3 incredible starts in which he has logged 22.2 innings and given up just 6 hits and 3 earned runs. Yamamoto also has some experience against the Giants, as he has pitched 18.2 innings giving up 10 hits and 6 earned runs. Moreover, San Francisco is batting .160 over the past 6 games. Yamamoto has also pitched 7+ innings in 4 of his last 5 starts. That is great news because the Giants can probably keep their bullpen off the mound. While normally we would give the bullpen edge to the Giants, their relievers have given up 21 runs over the past 5 games. All in all, we have a clear edge in hitting and Yamamoto in great form. I am taking the Dodgers to get the win at home.

Giants vs Dodgers prediction: Los Angeles ML (-160) available at time of publishing. Playable at that number.

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