San Francisco Giants vs Los Angeles Dodgers Prediction, Odds and Picks for Today, 09/21/25

The Dodgers took 2 out of 3 from the Giants in San Francisco last weekend, and have won each of the first 3 games in this series in Los Angeles. The two teams are set to wrap up their 4-game set on Sunday afternoon at Dodger Stadium. It’s the last regular season home game for the Dodgers. Los Angeles has been great at home all season long, owning a strong 52-28 record when playing in front of their home fans. They are just 36-39 on the road. The Dodgers are in another strong position to succeed in this one, as they are set to face San Francisco starting pitcher Trevor McDonald, who is making just his third career big league start. Going up against a Dodger offense that is rolling, McDonald has a tough task ahead of him.

The Dodgers will send Emmet Sheehan to the mound. Sheehan owns a strong 3.17 ERA and 1.06 WHIP through 13 games and 65.1 innings of work so far this season. The San Francisco offense hasn’t been able to find much success over the last few weeks, which has resulted in the Giants dropping 7 of their last 9 games. Given Los Angeles’ strong numbers at home, look for the Dodgers to complete the sweep in convincing fashion. Back the Dodgers on the run line -1.5.

Giants vs Dodgers prediction: Dodgers -1.5 (-110) available at time of publishing. Playable to -115.