San Francisco Giants vs Milwaukee Brewers Prediction, Odds and Picks for Today, 08/22/25

The second half has not been kind to the Giants. San Francisco started the second half 7 games over .500. Now, they find themselves 6 games under the .500-mark. They are just 7-12 in August and have dropped 10 of their last 12 games. On the other side, the Brewers are still arguably the hottest team in baseball. Despite dropping 3 of 5 against the Cubs, Milwaukee is 16-4 in August. The offense continues to shine, and Milwaukee continues to be great at home, owning a record of 42-20 at American Family Field.

Milwaukee’s Jose Quintana has allowed just 2 earned runs over his last 2 starts, and he is set to face a San Francisco lineup that hasn’t done much in recent weeks. The Giants ranks 26th in baseball in total runs this month, and they’ve struggled against lefties all season long. San Francisco’s .210 batting average and .614 OPS against southpaws this season are both the worst in baseball. Fade the Giants and back the Brewers in this one.

Giants vs Brewers prediction: Brewers ML (-160) available at time of publishing. Playable to -165.

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