San Francisco Giants vs San Diego Padres Prediction, Odds and Picks for Tuesday, 08/19/25

The San Francisco Giants will lean on rookie Kai-Wei Teng, who is still navigating the challenges of adjusting to Major League lineups. Teng carries a 9.90 ERA across his first 10 innings, a line that reflects his early struggles with command and run prevention. While his recent outing against Washington showed flashes of promise—five shutout innings with just three hits allowed—his overall inconsistency remains a concern. The Giants’ offense has been equally erratic, often struggling to produce against high-end pitching and ranking in the bottom tier of MLB in both batting average and slugging. San Francisco will need to play nearly flawless baseball on both sides to keep pace in this matchup, especially in the early innings where Teng has shown vulnerability.

The San Diego Padres, on the other hand, send out Nick Pivetta, who has been nothing short of excellent this season. The veteran right hander enters with a 2.87 ERA, 0.95 WHIP, and 144 strikeouts in 141.1 innings, providing stability and swing and miss stuff every time he takes the mound. Even in his rare off nights, Pivetta has demonstrated the ability to limit damage and keep San Diego in games. Backing him is a Padres offense that has been far more consistent than San Francisco’s, capable of generating early leads and putting pressure on opposing starters. With a clear advantage in both starting pitching and lineup production, San Diego is well positioned to strike early and maintain control throughout…especially after dropping game 1 last night.

Giants vs Padres Prediction: Padres ML (-215) available at time of publishing. Playable to that number

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