San Francisco Giants vs San Diego Padres Prediction, Odds and Picks for Today, 08/20/25

In this game, we will see the San Francisco Giants take on the San Diego Padres. Through the previous 2 games these teams have split. On the mound today, we have Landen Roupp of the Giants and JP Sears of the Padres. Roupp is coming off a brutal start where he gave up 5 runs in just 3 innings against the Tampa Bay Rays. On the year, Roupp has a 3.45 ERA with a 7-6 record. He has faced the Padres twice this year with very different outcomes. In the first meeting, he gave up 7 hits and 4 runs in just 4.1 innings. In the second meeting, he gave up 4 hits and 0 runs in 6.1 innings. It seems that the version of Roupp we will see may be determined by the Padres lineup. On the year, the Padres are batting .251 and hold a home record of 39-21. This home form is incredible and Roupp’s bad game against them was in San Diego.

For the Padres, they will start Sears who has only had one start for them. In his first start with the Padres, he gave up 10 hits and 5 runs in just 5 innings against the Arizona Diamondbacks. Similarly to Roupp, Sears has faced the Giants lineup twice this year. He also had one good game and one bad game. In his most recent meeting with the Giants, he pitched 6 innings giving up just 3 hits and no runs. In the first game, he gave up 6 hits and 4 runs in just 4 innings pitched. Luckily for Sears, the Giants are batting .220 over the last 6 games while only batting .212 against left-handed pitching, which ranks last in the MLB. These numbers are encouraging for Sears and the Padres. Another point of encouragement is the Padres bullpen. Over the past 2 games they have given up 0 runs to the Giants and currently hold the lowest ERA in the MLB. Overall, the Padres have the batting and bullpen advantage so I am taking them to get the win at home.

Giants vs Padres prediction: Padres ML (-155) available at the time of publishing. Playable at that number.

You can bet on our Giants vs Padres pick with BetMGM, where right now new users can activate your new BetMGM account ⚡ and receive $150 in bonus bets INSTANTLY if your first $10+ wager is a winner!