San Francisco Giants vs St. Louis Cardinals Prediction, Odds and Picks for Today, 09/05/25

The San Francisco Giants hand the ball to rookie right hander Carson Seymour, who is still adjusting to the majors after being promoted from Triple-A Sacramento. In the minors, Seymour flashed strikeout ability with over 10 K/9 but also dealt with command inconsistencies and bouts of hard contact. That trend has followed him into his first taste of MLB action, where he has carried a 4.74 ERA and 1.50 WHIP. His raw stuff plays, but he remains hittable, and against a contact heavy St. Louis Cardinals lineup featuring Nolan Arenado, Willson Contreras and Lars Nootbaar, limiting damage will be a tall order. San Francisco’s offense, meanwhile, has been inconsistent but does have the ability to capitalize on young arms — with Matt Chapman and Rafael Devers supplying much-needed power in the middle of the order.

On the other side, the Cardinals will send out their own rookie in Michael McGreevy, who has been steady but far from dominant in his first handful of big-league starts. Through 28.1 innings, McGreevy has posted a 4.17 ERA and 1.19 WHIP while showing good command but not overpowering hitters. He has proven capable of handling weaker lineups, but San Francisco’s blend of patience and power could present challenges, especially the second and third time through the order. St. Louis has been swinging the bats well in recent weeks, with Contreras and Masyn Winn showing signs of life at the plate. With 2 inexperienced arms taking the mound and both offenses showing enough depth to exploit mistakes, this matchup sets up as higher-scoring than a typical NL clash.

Giants vs Cardinals prediction: Over 8.5 (-105) available at time of publishing. Playable at that number.

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