San Francisco Giants vs St. Louis Cardinals Prediction, Odds and Picks for Today, 09/06/25

The San Francisco Giants look to stay red hot against the St. Louis Cardinals tonight as they continue their push for the final NL Wild Card spot. San Francisco has won 11 of its last 12 games and will look to keep the momentum going with Justin Verlander on the mound. Verlander enters with a 3-10 record and 4.29 ERA, but he looks like his old self lately, going 2-0 with a 1.64 ERA over his last two starts. 

For the Cardinals, Andre Pallante takes the mound with a 6-13 record and a 5.38 ERA. He’s dropped six straight starts, posting an 8.67 ERA over that stretch. The Giants’ offense, which has struggled for most of the season, is finally finding a spark. Rafael Devers has a 1.232 OPS, six homers, and 16 RBIs over his last 13 games. Willy Adames has crushed seven home runs with a 1.118 OPS in his last 13, while Heliot Ramos is batting .333 in his last 11. This is exactly the production San Francisco hoped for when they brought in Devers, and it couldn’t come at a better time. Verlander shouldn’t have an issue against a Cardinals team that’s averaging 3.5 runs per game over their last 10, which makes them my best bet of the day. 

Giants vs Cardinals prediction:  Giants ML (-130) available at time of publishing. Playable at that number.