Seattle Mariners vs Chicago Cubs Prediction, Odds and Picks for Today, 06/21/25

In this game, we will see the Seattle Mariners face off against the Chicago Cubs. Last night, the Mariners won the game 9-4 while hitting a team total of 4 home runs. On the mound today, we have Emerson Hancock of the Mariners and Cade Horton of the Cubs. Hancock has a 3-2 record with a 4.48 ERA. In his most recent start, he pitched 7 innings giving up 2 hits and 0 runs against the Cleveland Guardians. He will be hopeful to continue this form against a Cubs team that is batting .220 over the past 5 games. Another factor influencing faith in the Mariners is that Hancock has an away ERA of 3.31 only giving up 12 runs in 32.2 innings.

On the other side, we will see Horton take the hill. Horton has a record of 3-1 with a 3.47 ERA. He pitched great in his most recent start, going 5.2 innings giving up 3 hits and 0 runs to the Pittsburgh Pirates. The issue for the Cubs is that in half of his starts he has given up 3+ runs. The Cubs have also lost his last 2 starts. While the hitting of the Mariners has not been great, they are doing enough to win games. Though, that is not too difficult when the bullpen has not given up any runs over the past 5 games. Overall, I suspect that Hancock will continue his form against the struggling bats of the Cubs, and the Mariners bullpen will be able to continue their scoreless run. I am rolling with the Mariners to make it 2 in a row against the Cubs.

Mariners vs Cubs prediction: Seattle ML (+140) available at time of publishing. Playable at that number.

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