Seattle Mariners vs Houston Astros Prediction, Odds and Picks for Today, 09/19/25

The Mariners hand the ball to Bryan Woo, who has been one of their most consistent starters this season with a 14-7 record, 3.02 ERA, and 0.94 WHIP across 29 outings. He’s racked up 191 strikeouts while issuing relatively few walks, and his 21 quality starts show his ability to pitch deep into games and give his team a chance to win. Still, Woo’s 41.7% hard hit rate highlights some vulnerability when contact is made, and facing a Houston lineup that thrives on punishing mistakes could be a challenge. While Seattle’s offense has shown stretches of production, they have had trouble stringing together big innings against top end pitching, which may be a factor in this matchup.

For Houston, Hunter Brown has been a stabilizing force and one of the American League’s standout pitchers this season. He enters with a 12-7 record, 2.27 ERA and 1.00 WHIP through 174.1 innings, consistently limiting baserunners and generating weak contact. His recent outings have reinforced his ability to dominate when his command is sharp, and even with the Astros dealing with injuries throughout the lineup, Brown’s steady presence has kept them competitive. With Woo’s susceptibility to hard contact and Brown’s consistency at the top of the rotation, the Astros appear to have the advantage in this contest. Backing Astros ML looks like the stronger play, with Brown poised to keep Seattle’s offense in check while Houston’s bats provide enough support to secure the win.

Mariners vs Astros prediction: Houston ML (-110) available at time of publishing. Playable to -120.

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