Seattle Mariners vs Kansas City Royals Prediction, Odds and Picks for Today, 09/17/25

The Seattle Mariners face the Kansas City Royals again on Wednesday in the second of three games. The streaking Mariners have now won 10 games in a row, which has been enough to catapult them into the division lead, but only by half a game. They have done most of their damage with the bats, scoring in double digits in 4 of those 10 wins. With a showdown against the Astros looming this weekend, this is no time to relax. For the Royals, the story is the return of Cole Ragans. They had hoped to get Ragans back in time for a playoff push, but they have since faded well out of the race. A lot of sharp money is coming in on the Royals already today, but I am not interested in betting against this hot Mariners team. Give me the Seattle Money Line.

Ragans has not pitched in the Big Leagues since early June, missing 3 months with a shoulder injury. He will definitely be on a limited pitch count, and betting on immediate success after a long layoff is usually folly on our part. The Mariners will go with Bryce Miller, who is vulnerable, having given up 4 runs in 3 of his 5 starts since returning to the rotation. He did look better in his last outing though as he fanned 11 Angels (who are always good for one’s strikeout numbers). Even if Ragans is the more effective pitcher, he won’t be out there long, and I have a hard time betting against this Seattle offense right now, especially given the general struggles of the Royals on offense all season long anyway. I’ll keep riding with the Mariners.

Mariners vs Royals Prediction: Mariners ML (-105) available at the time of publishing. Playable at that number.