St. Louis Cardinals vs Milwaukee Brewers Prediction, Odds and Picks for Friday, 09/12/25

The St. Louis Cardinals turn to Andre Pallante, who has endured a rough 2025 campaign. Entering this matchup, he owns a 6-13 record with a 5.28 ERA and 1.43 WHIP, struggling to find consistency in his outings. Over his last 9 starts, Pallante has allowed 32 earned runs in 44.2 innings, as both walks and hard contact have plagued him.

While his ground ball tendencies and modest barrel rate offer glimpses of upside, he’s too often left pitches over the plate, leading to crooked innings. Offensively, the Cardinals have leaned on contributions from Alec Burleson and Willson Contreras, but the lineup has been inconsistent in providing run support, especially when the rotation struggles to keep them in games early.

The Milwaukee Brewers counter with Quinn Priester, who has been one of their steadiest arms this season. Priester carries a 12-2 record with a 3.25 ERA and 1.23 WHIP across 141.1 innings, backed by 113 strikeouts. He’s coming off another strong performance against Pittsburgh, tossing 7 innings of 2-run ball with 6 strikeouts and just 1 walk, showcasing his ability to work efficiently while keeping hitters off balance.

Milwaukee’s offense, powered by Christian Yelich’s veteran presence and William Contreras’ production in the heart of the order, has given Priester consistent run support, making him especially tough to beat. A fun fact that Milwaukee bettors will enjoy is that the Brew Crew is 14-0 in its last 14 games with Priester on the mound. Do what you will with that information. With the clear pitching edge and a more reliable offense, the Brewers are in prime position to take control of this matchup.

Cardinals vs Brewers Prediction: Brewers ML (-184) available at time of publishing. Playable to -200.

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