St. Louis Cardinals vs Tampa Bay Rays Prediction, Odds and Picks for Today, 08/21/25

In this game, we will see the St. Louis Cardinals take on the Tampa Bay Rays. These are 2 teams with very similar statistics on the year that sit well outside of the playoff picture. On the mound today, we have Sonny Gray of the Cardinals and Joe Boyle of the Rays. Gray has a 4.30 ERA with an 11-6 record on the season. In his most recent start, he gave up 6 runs in 5 innings against the New York Yankees. Prior to that start, he had 2 starts where he gave up 2 total runs through 14 innings. While his recent start is concerning, the Rays are not hitting the ball as well as the Yankees. The Rays are batting .203 over the past 5 games while averaging 3.4 runs.

For the Rays, Boyle will take the mound. Boyle is coming off 2 brutal starts where he has given up 10 runs in just 3.1 innings. The bigger issue with these starts is that they were against the Seattle Mariners and San Francisco Giants. These are 2 teams that hit worse than the Cardinals. The Cardinals come into this one batting .248 over the past 6 games while averaging 5.3 runs per game. The runs are coming easy to the Cardinals right now and I do not see Boyle being able to stop that. Outside of the starters, the Cardinals’ bullpen has continued to improve as the season goes on. The opposite can be said for the Rays, as their bullpen has given up 13 runs over the past 3 games. Overall, I believe in Gray and I think the Cardinals have the hitting and bullpen edge. I am taking the Cardinals to get the win on the road.

Cardinals vs Rays prediction: Cardinals ML (-120) available at time of publishing. Playable at that number.

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