Tampa Bay Rays vs Baltimore Orioles Prediction, Odds and Picks for Today, 09/23/25

Neither the Orioles nor the Rays expected their season to unfold this way, with both finishing at the bottom of the AL East. As they open a 3-game series, pride is the only thing on the line. Regardless of where they are in the standings, both starters will look to finish strong and try to end the year with a winning record. 

Taking the mound for the Rays will be Ryan Pepiot, who enters with a 11-11 record and a 3.77 ERA. For the Orioles, Dean Kremer is starting. He is 10-10 with a 4.39 ERA. Pepiot has been the better pitcher lately, going 3-2 with a 3.22 ERA in his last 5 starts; Kremer has posted a 5.70 ERA in that same stretch despite a 2-1 record. Both teams are 4-6 in their last 10 games, with the Rays averaging 4.1 runs per game in that span compared to the Orioles’ 2.8. At the end of the day, neither team has a lot to play for — but the Rays should do enough in this one to help Pepiot pick up a win on Tuesday night.

Rays vs Orioles prediction: Tampa Bay ML (-115) available at time of publishing. Playable at that number.

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