Tampa Bay Rays vs Baltimore Orioles Prediction, Odds and Picks for Today, 09/25/25

The Tampa Bay Rays and Baltimore Orioles wrap up their three-game series on Thursday, with the Rays aiming to secure a series win. Taking the mound for the Rays will be Drew Rasmussen, who enters with a 10-5 record and a 2.80 ERA. Rasmussen was one of the Rays most reliable arms earlier in the season, but he hasn’t been able to secure a win since August 13. Over his last six starts, he’s gone 0-0 with a 3.60 ERA. 

For the Orioles, Cade Povich will get the start, entering with a 3-8 record and a 5.06 ERA. Looking at Povich’s last six starts, he’s 1-2 with a 5.34 ERA. The Rays have the slight advantage on the mound with Rasmussen, however, he typically doesn’t go deep into the game. That shouldn’t be too much of a concern for the Rays, as their bullpen holds a 3.69 ERA on the season compared to the Orioles who have a 4.62 ERA. There’s one thing the Rays are looking to do before their season ends, and that’s to end the season on a winning streak. Look for the Rays to secure a win, bringing their win streak up to two.  

Rays vs Orioles prediction: Tampa Bay Rays ML (-130) available at time of publishing. Playable at that number.

If you’re looking for a new sportsbook for the football season, we recommend checking out Fanatics Sportsbook. New users can get up to $100 back in FanCash EVERY GAMEDAY UNTIL OCTOBER if their football bet loses! Join Fanatics Sportsbook, where you can bet on our Rays vs Orioles predictions.