Tampa Bay Rays vs Chicago White Sox Prediction, Odds and Picks for Today, 09/10/25

The Tampa Bay Rays turn to right hander Griffin Jax, a midseason acquisition from Minnesota who’s been asked to stretch into bigger innings. On the year, Jax carries a 4.81 ERA and 1.38 WHIP across 58 innings, striking out 89 batters while showing excellent chase metrics that rank among the league’s best. His ability to generate swings outside the zone has been a weapon, but when opponents make contact, he can be vulnerable, giving up damaging hits in key spots. The Rays’ offense has remained streaky, relying on balanced production rather than superstar production, but consistency has been an issue, particularly against right handed pitching. Tampa Bay’s reliance on its bullpen depth is always a factor, yet Jax’s role as the opener/type starter creates uncertainty in how deep he’ll work in this matchup.

For the Chicago White Sox, the expected starter (not finalized) is Sean Burke. He continues to hold down a rotation spot and has shown flashes of steady improvement. Over 117.2 innings, Burke owns a 4.28 ERA with 110 strikeouts, though occasional inefficiency leads to higher pitch counts and shorter outings. Still, his recent form has been encouraging, limiting damage while missing bats more consistently. The White Sox lineup has shown life in recent weeks, led by Andrew Benintendi, who has surged with a 1.196 OPS in September, and Chase Meidroth, who’s batting .375 over his last stretch. With Chicago winning seven of its last ten, they’ve found a rhythm both offensively and on the mound. Given Jax’s volatility and Burke’s ability to keep the game manageable, the better play is on White Sox +1.5 instead of the ML to be safe.

Rays vs White Sox Prediction: White Sox +1.5 (-145) available at time of publishing. Playable to that number