The Athletics vs Pittsburgh Pirates Prediction, Odds and Picks for Today, 09/19/25

In this game, we will see the Athletics take on the Pittsburgh Pirates. These are 2 teams trending in opposite directions. The Athletics have won 6 of their last 7, while the Pirates have lost 11 of their last 12. Looking at today, we will see Luis Severino of the Athletics and Mitch Keller of the Pirates take the mound. Severino has struggled in his past few games, giving up 8 runs in just 10 innings pitched. While normally this would concern me, he has a 3.11 away ERA only giving up 26 runs in 75.1 innings pitched. Additionally, the Pirates are batting .190 over the last 6 games, while ranking last in runs scored on the season. I suspect we will see a good outing by Severino.

For the Pirates, Keller will take the hill. Keller has a 4.13 ERA on the season with a 6-14 record. While he has pitched well in recent form, the Pirates have still managed to lose 5 of his last 6 games. This is bad when we consider that he will go up against an Athletics lineup that is .268 with 32 runs over the past 6 games. Outside of the starters, the Athletics bullpen has only given up 3 runs over the past 5 games. Given Severino’s improved form in away games, the hitting edge of the Athletics, and the incredible bullpen play, I am taking the Athletics to get the win today.

Athletics vs. Pirates Prediction: Athletics ML (-110) available at the time of publishing. Playable at that number.

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