The Athletics vs St. Louis Cardinals Prediction, Odds and Picks for Tuesday, 09/02/25

In this game, we will see the Athletics take on the St. Louis Cardinals. Yesterday, the Athletics dominated the Cardinals and won the game 11-3. On the mound today, we have Luis Severino of the Athletics and Miles Mikolas of the Cardinals. Severino has given up 29 hits and 18 runs in his last 32 innings pitched. This is a slight improvement from his numbers on the rest of the season. He has also been able to make it through the 5th innings in his last 4 starts, contributing to the Athletics winning all 4. Severino’s ability to limit hits and keep walks to a minimum could come in handy today against a Cardinals team that is batting .198 over the past 7 games. Additionally, the Cardinals were only able to get 5 hits off Luis Morales yesterday, and Severino has a huge experience advantage.

For the Cardinals, Mikolas will take the mound. In the month of August, Mikolas has a 6.04 ERA giving up 29 hits and 15 runs in 22.1 innings pitched. Mikolas also holds a 6-10 record this season with the Cardinals losing 3 of his last 5 starts. Today, he will face an Athletics lineup that is batting .274 over the past 6 games. The Athletics were also able to accrue 15 hits and 11 runs last night. This is not the form you want against Mikolas. Outside of the starters, the Cardinals have the bullpen edge. Overall, I am going to trust Severino’s recent form against a struggling Cardinals lineup. I am rolling with the Athletics to get the win today. I love a good Mikolas fade.

Athletics vs Cardinals prediction: Athletics ML (-110) available at time of publishing. Playable at that number.

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