The Athletics vs St. Louis Cardinals Prediction, Odds and Picks for Wednesday, 09/03/25

The Athletics and Cardinals are set for a rubber match on Wednesday night at Busch Stadium. Interestingly enough, St. Louis starting pitcher Matthew Liberatore has struggled when pitching in this home ballpark this season. His ERA jumps from 4.13 on the road to 4.55 at home, and his BAA goes from .258 to .283. The Athletics exploded for 11 runs in the series opener on Monday, but managed to score just a single run in Tuesday’s contest. The Athletics own a strong .754 team OPS against lefties this season, which ranks 7th in all of baseball. They should be able to bounce back with a strong performance at the plate against Liberatore.

Jeffrey Springs will get the starting nod on the mound for the Athletics. He has been great on the road this season, owning a 3.66 ERA and .217 BAA when pitching away from Sacramento. He will face a St. Louis lineup that has struggled to score runs on a consistent basis all season long. The Cardinals don’t hit a ton of home runs, and have just scored 5 total runs in the first 2 games of this series. Even at home, the Cardinals are hard to trust. Back the Athletics on the road.

Athletics vs Cardinals prediction: Athletics ML (-110) available at time of publishing. Playable at that number.

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