Washington Nationals vs Chicago Cubs Prediction, Odds and Picks for Today, 09/06/25

It’s time for some Saturday afternoon baseball as the Washington Nationals and Chicago Cubs get set to take the field for game two of their series. The Cubs had little trouble in game one, cruising to an 11-5 victory. In Saturday’s matchup, they’ll hand the ball to left-hander Matthew Boyd, who enters with a 12-7 record and a 2.94 ERA. 

For the Nationals, Brad Lord will get the start, entering with a 4-8 record and a 4.34 ERA. It’s not an ideal matchup for Washington, as Lord has struggled recently, going 1-2 with a 12.08 ERA in his last three starts. Not to mention Lord last faced the Brewers back on August 3rd where he gave up three earned runs on six hits in just 4.2 innings pitched. The Cubs have the pitching advantage in this one with Boyd on the mound, plus they have the advantage at the plate since the Cubs are averaging 5.1 runs per game in their last 10 compared to the Nationals 3.6. Look for Boyd and the Cubs to get the job done and secure an early series win.

Nationals vs Cubs prediction: Cubs -1.5 (-125) available at time of publishing. Playable at that number.

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