Washington Nationals vs Chicago Cubs Prediction, Odds and Picks for Today, 09/07/25

The Washington Nationals and Chicago Cubs will wrap up their three-game series on Sunday, and we’ve got your prediction right here! The Nationals defeated the Cubs 2-1 on Saturday, and they’ll hand the ball to rookie Andrew Alvarez for the last game in this series. Alvarez made his first appearance in the big leagues back on September 1st, pitching five scoreless innings, allowing just one hit against the Marlins.

For the Cubs, they’ll likely roll with their bullpen in this one, giving Drew Pomeranz the start who enters with a 2-1 record and a 2.45 ERA. In the Cubs last 10 games, they’re averaging 5.0 runs per game compared to the Nationals 3.3. Alvarez was solid in his last start, I’ll give him that, but this Cubs team is a completely different ball team than the Marlins. At the end of the day, it’s hard to trust a team that has no shot at making the post season. Look for the Cubs to get to the rookie early on and take advantage of a weak Nationals bullpen, making Chicago my best bet of the day. 

Nationals vs Cubs prediction: Cubs -1.5 (+105) available at time of publishing. Playable at that number.