Washington Nationals vs Miami Marlins Prediction, Odds and Picks for Today, 09/10/25

The first 2 games of this series have produced a total of 34 runs. In a pitching matchup between Washington’s Jake Irvin and Miami’s Yuri Perez, Wednesday’s matchup could be another high-scoring affair. Irvin has struggled on the road all season long, as he owns a less-than-ideal 6.19 ERA and .282 BAA away from Nationals Park. Overall, he has allowed at least 4 earned runs in 5 of his last 7 starts. The Marlins don’t hit lefties particularly well, but with the way he is pitching right now, Miami should be able to have success at the plate in this one.

On the other side, Perez is set to face a Washington lineup that leads the league with 45 runs scored over the last week. The Nationals are locked in at the plate right now, and they should be able to keep things rolling against Perez. The young right-hander has allowed 12 earned runs over his last 2 outings, tossing just 4.2 innings in that span. Both bullpen own ERA’s well above 4, which means we could have another high-scoring game on our hands. Look to the over.

Nationals vs Marlins prediction: Over 8.5 (-105) available at time of publishing. Playable to -115.