Washington Nationals

Washington Nationals vs New York Mets Prediction, Odds and Picks for Today, 09/21/25

Citi FieldMAS2, SNY
Nationals
63-92
Nationals
Today
Mets
80-75
Mets

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New York Mets
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Nationals vs Mets Pickswise Expert Predictions

Washington Nationals
Run Line Pick
NY Mets -1.5(-130)

The Washington Nationals will look to steal a series win against the New York Mets on Sunday and spoil their division rivals’ playoff hopes. The Mets currently hold a one-game lead in the NL Wild Card standings and will send left-hander Sean Manaea to the mound. Manaea enters with a 2-3 record and a 5.40 ERA, coming off his first win since July 23. 

For the Nationals, Jake Irvin will get the start, entering with a 8-13 record and a 5.76 ERA. Irvin has dropped six straight outings, posting a 8.79 ERA with 19 strikeouts in 28.2 innings pitched. Offensively, the Mets are averaging 5.0 runs per game in their last 10 compared to the Nationals 3.2. Unfortunately for the Nationals, I don’t think they’ll be playing spoiler in today’s matchup, especially with Irvin on the mound. I expect the Mets offense to get to Irvin early in this one and secure a much needed win to keep their playoff hopes alive. 

Nationals vs Mets prediction: Mets -1.5 (-130) available at time of publishing. Playable at that number.

New York Mets
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Jason Fragomeni

Jason Fragomeni is a MLB sports writer for Pickwise who lives in New York and is a huge fan of the New York Yankees and New York Giants. Jason is a data/statistic fanatic and he’s learned how to apply statistical analyses into the sports betting world. Jason uses data every day to help him determine what picks have the greatest probability of winning, which has helped him when it comes time to make a wager. Jason has been in the sports industry for over 10 years now, and has a wealth of knowledge surrounding sports and is a sports bettor by hobby.
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