Cleveland Cavaliers vs New York Knicks Prediction, Odds and Picks for Wednesday, 10/22/25

We can start with the obvious – the Knicks on opening night in the Garden, you can expect to pay a premium to back New York here before we go any further. New York made it to the Eastern Conference Finals in the 2024-25 season and though we have not played a minute of basketball, the discussion here is can the Knicks get to the Finals this season finally? Cleveland we remind everyone was the top seed in the East, last season, but no one is talking about them.

It would go against conventional wisdom to back the Cavaliers here perhaps and even go as far as to suggest that they can win this game outright. But is that really absurd? The Cavs have the perimeter shooting threat that can give New York fits and when this team fires on all cylinders, they can light it up quick. New York meanwhile may caught up in the spectacle and revelry that comes with opening night in the Garden. Yes, we say it again.

But opening night is all about surprises and it wouldn’t be all that crazy if Cleveland swoops in and steals a win? Not by the least, especially is Donovan “The Spider” Mitchell gets going from beyond the arc. Cavaliers pull the upset.

Cleveland vs. New York prediction: Cleveland +145 (Money Line), available at time of publishing. Playable to number posted.