HomeNBANBA PredictionsCleveland Cavaliers vs Philadelphia 76ers Prediction, Odds and Picks

Cleveland Cavaliers vs Philadelphia 76ers Prediction, Odds and Picks for Today, 01/14/26

Updated: 9:53 AM ET Jan 14, 2026

Xfinity Mobile ArenaESPN

Cavaliers

7:10 PM ETToday

76ers

LWLWL	Last 5	LWWLW
22-19	Record	22-16
13-27-1	ATS Record	19-18-1
19-22	O/U Record	20-18

Vote on who will win!

Cavaliers vs 76ers Pickswise Expert Predictions

Money Line Pick

CLE Cavaliers Win(-105)

Reasoning

Let’s start with the number – this is a virtual toss-up. In a 50/50 spot like this one, taking the reduced price on the dog is the move here because it has the most value. That’s Cleveland in this case. But let’s also dive deeper, Cleveland remains one of the worst covering teams in the NBA on the season at 12-29 while the Sixers are one of the best at 23-14-1. This means that by default, the Cavaliers are undervalued here while Philadelphia is prone to being overvalued. Once again that points to the value resting with the visitors.

You will hear that this game will be a playoff-type of tilt with an animated atmosphere. That’s true, but that never prompted the Cavaliers to be shy in these situations. The Cavaliers have lost games on the road against postseason caliber outfits that they should have won. Cough, cough – New York on Christmas Day. The Cavaliers have defeated the Sixers already this season in a 132-121 win that saw the Cavs shoot lights out against Philadelphia. The point is, Cleveland has a recipe for success it can duplicate here, and they should not be the underdog. Because of trends and ATS measurables, Cleveland is the underdog by that reason alone. Wrong side favored.

Cavaliers vs 76ers prediction: Cavaliers ML (-105) available at time of publishing. Playable at that number.

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College football handicapper for Pickswise, specializing in college football, soccer and college basketball. Much prefer betting on the smaller/forgotten games than the big matchups, where the lines are a lot more vulnerable. PhD in Victorian Literature, putting my skills of the written word to the test with betting analysis.

Same Game Parlay

Player Points

D. Mitchell (CLE) - 30+ pts

Player Points

T. Maxey (PHI) - 30+ pts

Reasoning

Donovan Mitchell to score 30+ points (+144)

Although his scoring is slightly down in January compared to the month prior, Donovan Mitchell is still putting up points at a high rate. He’s cleared the 30-point mark 4 times over his last 6 outings, and Wednesday is a really solid opportunity for him to add to that number. I’m expecting a response from him after one of his more disappointing performances of the season, where he had just 21 points in a double-digit loss to the Jazz the other day. The Cavs laid an egg as a team in that game, going into it as double-digit favorites, but ultimately falling to one of the worst teams in the league. As the leader of this team, Mitchell should be at the forefront of the response against Philadelphia.

Mitchell has already had one stellar performance against the 76ers this season, scoring 46 points on them back in early November, which is actually his 2nd-highest scoring game of the season. In his last visit to Philly, Mitchell also dropped 37 points and dished out 7 assists. Tyrese Maxey just isn’t built to handle a player like Mitchell on the defensive end. The 76ers allow the 2nd-most points to opposing shooting guards this season, so I fully expect Mitchell to explode tonight.

Tyrese Maxey to score 30+ points (+142)

I mentioned Maxey in a negative way in terms of his defending ability, but he more than makes up for those deficiencies on offense for the Philadelphia 76ers. Entering Wednesday’s game, he’s currently averaging 30.9 points per game in his last 10 outings overall, while shooting an incredible 53% from the field and 46% from three. He just had back-to-back games of 33 or more points against the Raptors, and right now, you’ll be hard-pressed to find a player in the NBA as hot as Maxey is on the offensive end.

The last 3 meetings vs the Cavs have seen him score 27, 29 and 27 points, and in the 2 most recent games, he shot 50% from the field on both occasions. With that type of consistency plus the current hot streak he’s on, I feel like he can have a big impact on the game with his scoring tonight. Cleveland ranks 10th for points allowed this season and they’ll have a hard time dealing with Maxey’s combination of speed and agility. The Sixers guard has cashed this line in 5 of 8 games, while for the season he’s done it in 53% of games played. With that type of success rate for a bet priced at these odds, I’ll happily include it in my Cavaliers vs 76ers parlay.

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Cavaliers vs 76ers Same Game Parlay

Top Trends

Point Spread

The 76ers have covered the spread in their last 3 home matchups with the Cavaliers.

Money Line

The 76ers have won 12 of their last 20 games against teams with winning records.

Game Totals

9 of the Cavaliers' last 10 matchups with the 76ers have gone over the Total.

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