Detroit Pistons vs Chicago Bulls Prediction, Odds and Picks for Today, 10/22/25

At first glance, who wouldn’t gravitate towards Detroit? After all, the Pistons beat the Bulls in three straight games last February. Detroit’s last impression was a hard-fought playoff series against the Knicks, where they consistently flirted with victory before falling short in the final minutes. One could argue they were a few bounces away from a second-round appearance — and that wouldn’t be far-fetched.

Chicago, on the other hand, didn’t leave such a good impression the last time they were on the floor. The Bulls endured a play-in loss to Miami, a team that was promptly dismantled by Cleveland in Round 1. On paper, that should make this a straightforward call: ride with Detroit.

However, the market isn’t treating Detroit like the clear favorite. In fact, the spread is modest — surprisingly so for a team with better recent form and dominance in the matchup history. That subtle hesitation speaks volumes. If the Pistons truly were a tier above, it would be reflected in the line. Instead, we are seeing the opposite. Roll with the Bulls in an opening night shocker.

Detroit vs. Chicago prediction: Chicago ML (+120) available at time of publishing. Playable to number posted.

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