Indiana Pacers vs Cleveland Cavaliers Prediction, Odds and Picks for Today, 11/21/25

There is a lot to unpack here, so we’ll start with the rivalry in itself. Cleveland and Indiana are no strangers to ill feelings, they are divisional foes after all. We can simply lean into the point spread here given the fact that there is a level of volatility and impredictiability that comes with divisional rivalry games like this one. Add in that Indiana eliminated Cleveland last year in the playoffs and the bitterness is that much greater. After all, The Land were the top seed in the East and Indiana crashed the party.

But forget all that, that just adds fuel to the offensive fire. If Cleveland gets up big like the point spread line anticipates (-13), then Cleveland may run it up to the send the Pacers a message. Then there is the flip side, Cleveland leads with their offense and loves the three. If the Cavs make their shots consistently and allow Indiana some open looks due to a full-court game, the scoring will be explosive here. Finally, a third possibility, Cleveland gets up big and Indiana plays a full game regardless where they take advantage of bench rotations and softer defense. As a result, there are numerous pathways for the score to get up there in this game and multiple avenues to this contest going over the total. That’s the play here – the over.

Pacers vs. Cavaliers prediction: Over 238.5 (-110) available at time of writing. Playable at the number.

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