Los Angeles Lakers vs Boston Celtics Prediction, Odds and Picks for Today, 12/05/25

Boston enters tonight riding one of its strongest stretches of the season, having won 8 of its last 10 and finally hitting the groove many expected after a slow start. Even on the second night of a back-to-back, the Celtics are in a favorable position because Jaylen Brown sat yesterday with an illness, leaving him fresh for this matchup. Their overall rhythm on both ends has tightened — ball movement is sharper, defensive rotations are crisp, and role players like Jordan Walsh have taken meaningful steps. Walsh’s defensive activity and ability to impact possessions without needing touches have added valuable versatility to Boston’s second unit. This improved depth is a big reason why the Celtics continue to handle these scheduling spots effectively.

The Lakers, however, enter at a clear disadvantage. They’re also on a back-to-back but will be without LeBron James, and Luka Doncic remains out for personal reasons — removing two key playmakers and scorers. Without them, the offensive ceiling drops dramatically, and LA has to rely on Austin Reaves and secondary creators who have struggled to sustain efficient offense for a full 48 minutes. Boston’s improved defensive cohesion, plus their current momentum, sets up a difficult scenario for a shorthanded Lakers team that likely won’t be able to keep pace. Given the trajectory of both sides and the talent gap created by the absences, this projects as a strong spot for Boston at home.

Lakers vs Celtics Prediction: Boston Celtics -6.5 (-110) available at time of publishing. Playable to -7.

If you’re looking for a new sportsbook, check out Bet365, the world’s #1 sportsbook. They have an amazing sign-up offer where you can INSTANTLY receive $150 in bonus bets from a $5 wager, regardless of whether that bet wins or loses! There’s no catch, it’s really that simple. Join Bet365 right now ⏰ in time to fade or follow our experts’ Lakers vs Celtics predictions.