Memphis Grizzlies vs Cleveland Cavaliers Prediction, Odds and Picks for Today, 11/15/25

The Memphis Grizzlies are going through a rough patch in form, having won just one of their last 5 games. What makes matters worse is the fact that each of those losses were double-digit defeats. Thinks will not get any easier for them tonight as they travel on the road to take on the Cleveland Cavaliers. The visitors are 27th in the league in points differential when playing on the road, losing by an average of 14.8 points. They have a depleted backcourt even with the return of Ja Morant tonight, with Ty Jerome and Scotty Pippen Jr. ruled out and promising rookie Cedric Coward listed as doubtful to play.

Jaren Jackson Jr. is off to a slow start this year, averaging 5 fewer points per game than he did last season. The Cavaliers and even Mobley will not be a favorable matchup for him tonight either. They held him to close to 5 fewer points per game in their matchups last season compared to his season average and should be able to similarly stifle him here. The Cavaliers should also be able to outgun their opponents from the perimeter. The hosts are second in the league in 3-point makes per game while the visitors are all the way down in 19th. Overall the Cavaliers are 8th in offensive rating this season and its hard to see a dysfunctional Grizzlies team keeping pace.

Grizzlies vs Cavaliers prediction: Cavaliers -10.5 (-110) available at time of publishing. Playable to Cavaliers -11.5.