Minnesota Timberwolves vs Los Angeles Lakers Prediction, Odds and Picks for Friday, 10/24/25

The Minnesota Timberwolves opened their season with an emphatic 118-114 win over the Portland Trail Blazers, led by a dominant 41-point, 7-rebound performance from Anthony Edwards — who looked every bit like a superstar ready to carry this team forward. With a year of chemistry now built around last offseason additions in Julius Randle and Donte DiVincenzo, Minnesota looks poised to take a real step forward this season. Randle adds a needed interior scoring and rebounding presence, while DiVincenzo provides spacing and defense on the perimeter. Head coach Chris Finch’s squad seems to have found a balance between offensive firepower and defensive grit, and that combination should make them one of the tougher teams to handle in the Western Conference.

The Los Angeles Lakers, on the other hand, enter this matchup looking to rebound from a 119-109 loss to the Golden State Warriors despite Luka Doncic’s monster performance — 43 points, 12 rebounds and 9 assists. The absence of LeBron James for an extended stretch leaves a significant leadership void, forcing others like Austin Reaves (26 points in the opener) to shoulder more responsibility. However, the supporting cast underwhelmed — with Rui Hachimura managing just 9 points and Gabe Vincent 3. There hasn’t been much line movement for this matchup, and while the public leans toward Minnesota, that’s a side worth backing. The Timberwolves’ defense should suffocate a Lakers team still trying to find offensive rhythm without LeBron, and Minnesota’s 2-way balance give it the edge.

Timberwolves vs Lakers Prediction: Minnesota -2.5 (-110) available at time of publishing. Playable to -3.5.

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