New Orleans Pelicans vs Memphis Grizzlies Prediction, Odds and Picks for Wednesday, 10/22/25

While it’s hard to put too much weight on preseason games, the signs for the Memphis Grizzlies do not loot promising. The team have suffered some heavy losses to the likes of the Charlotte Hornets and seem to be struggling to get by after the Desmond Bane trade. Ja Morant is yet to make an appearance too but could be in line to start the season. Do not be surprised if he is rusty to start. With Zach Edey due to miss time too, the Grizzlies should struggle early in the season. The Pelicans on the other hand have Zion Williamson ready to start the season and in arguably the best shape of his career. While Dejounte Murray and Kevon Looney will not be available to start the season, the likes of Jose Alvarado should be able to step in.

The Pelicans have a couple of wing defenders in Trey Murphy III and Herbert Jones who should be able to cause issues for the Grizzlies role players. Murphy III had a breakout season last year offensively, averaging 21.2 points per game. He should prove to be a great running mate for Williamson, especially with his floor spacing ability. Without Looney in the paint the Pelicans could lack rim protection but the absence of Edey should make it tough for the hosts to capitalize. With Jaren Jackson Jr. acting more as a perimeter threat, it could play into the hands of the Pelicans. Take the points on them here.

New Orleans Pelicans +3 available at time of publishing. Playable at that number.