Philadelphia 76ers vs Cleveland Cavaliers Prediction, Odds and Picks for Today, 11/05/25

The Philadelphia 76ers visit the Cleveland Cavaliers on the second night of a back to back, which likely means no Joel Embiid due to load management. Interestingly, the Sixers have actually flourished offensively without him, averaging 132.5 points per game compared to 120 when he plays — yes, against softer opponents like the Nets and Magic. Still, the pace and spacing improve when Tyrese Maxey is running the show, and wings like Kelly Oubre Jr. tend to see more touches and production in Embiid’s absence. Nick Nurse’s squad has leaned on its guard depth to stay efficient and aggressive in transition, and with Maxey’s ability to penetrate and find shooters, Philadelphia’s offense has proven adaptable even without its ex-MVP center.

Cleveland, meanwhile, enters this game rested, but far from dominant. Darius Garland remains questionable with a toe injury, and Jarrett Allen’s status could again be in doubt — two key pieces that impact both ends of the floor. The Cavaliers rank just 23rd in offensive rating, struggling at times to create consistent half court looks beyond Donovan Mitchell’s shot creation. With potential absences inside, Cleveland could have trouble exploiting the Sixers’ smaller frontcourt. While the Cavs are favored by around 10 points at home, that number feels inflated given Philadelphia’s offensive rhythm without Embiid and Cleveland’s early inconsistency. Expect Philly’s pace and guard play to keep this one competitive deep into the game.

76ers vs Cavaliers Prediction: 76ers +10.5 (-110) available at time of publishing. Playable to +8.5

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