Portland Trail Blazers vs Golden State Warriors Prediction, Odds and Picks for Friday, 11/21/25

The Portland Trail Blazers enter San Francisco with a strong underdog resume at 6-2 ATS, but their performance dips significantly on the road — where they sit just 2-6 ATS. Golden State, meanwhile, has been flawless at home with a 5-0 ATS mark — consistently feeding off the Chase Center crowd. These teams met in late October, when Portland stunned the Warriors with a 139-119 blowout — a result that still lingers as Golden State gears up for a revenge spot. In that game Portland benefited from big offensive showings; Deni Avdija dropped 26 points with 6 assists and Jerami Grant added 22 off the bench, showcasing the depth and versatility that can make the Blazers dangerous when everything clicks.

For Golden State, Stephen Curry’s 35 points kept them competitive that night — but the Warriors were undone by 25 turnovers, sloppy execution and a lack of defensive sharpness. At home, however, the Warriors have played much more disciplined basketball with cleaner ball movement and steadier defensive rotations. Their veterans tend to set the tone in these environments, and Golden State’s defensive numbers tighten significantly on their home floor. With Portland struggling to replicate strong performances away from home and Golden State holding a perfect home ATS record — combined with a clear revenge angle after being embarrassed last month — the momentum and situational edge lean heavily toward the Warriors.

Trail Blazers vs Warriors prediction: Golden State -7.0 (-120) available at time of publishing. Playable to -8.

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