San Antonio Spurs vs Dallas Mavericks Prediction, Odds and Picks for Wednesday, 10/22/25

The NBA season tips off this week, and we get to be treated as fans with a very intriguing matchup Wednesday night when the San Antonio Spurs travel to Dallas to take on the Mavericks. This feels like the year for the San Antonio Spurs where they take that next big step forward to becoming a playoff team. This is Victor Wembanyama’s 3rd season in the NBA. The Spurs were one of the worst teams in the NBA in his first year, they were competitive last year but still missed the postseason, and now expectations are present in year three. The Spurs won all five preseason games and will be looking to start fast this season. The Dallas Mavericks also had a successful offseason. After trading away Luka Doncic halfway through last season, the Mavericks were surprisingly granted the number one draft pick. Dallas selected rookie phenom Cooper Flagg, capping off a trade that somehow worked out for both teams. With players such as Kyrie Irving and Anthony Davis, the Mavericks should be able to continue their winning ways this season.

Starting point guards for each team will be out with injuries for the opener. The Spurs will be missing De’Aaron Fox, and Kyrie Irving is expected to be out with injury until at least 2026. With Irving out of the lineup, it leaves a big question mark in the Dallas Mavericks’ lineup of who will handle the basketball and distribute early this season. Dallas still has a roster that was constructed around Doncic running the offense. With Doncic gone, that leaves D’Angelo Russell as the only proven ball handler suiting up for opening night. Dallas has hope that Flagg can fill that role eventually, but in his first NBA game matched-up against Devin Vassell and Stephon Castle, we may see some growing pains out of the rookie. The Spurs are contenders in the West this season, and I have them starting their season with a big in-state win.

Spurs vs Mavericks prediction: Spurs ML (+130) at the time of publishing. Playable at that number.

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