San Antonio Spurs vs Los Angeles Lakers Prediction, Odds and Picks for Today, 11/05/25

The San Antonio Spurs enter Wednesday’s matchup against the Los Angeles Lakers riding early season momentum, starting 5-1 behind a top tier defense and a much improved offensive rhythm. They’re averaging roughly 118 points per game while allowing just over 103 — an impressive margin that’s turned heads around the league. Still, this feels like a sell high point for San Antonio. Their schedule has leaned favorable so far, and facing a veteran Lakers team on the road presents a different level of challenge. The Spurs’ young core, led by Victor Wembanyama and Devin Vassell, has shown excellent progression, but consistency and composure in tough environments remain a question mark.

The Lakers, on the other hand, have quietly found their groove at home, winning four straight at Crypto.com Arena and sitting at 6-2 overall. Their mix of experience, defense, and tempo control makes them tough to beat when they dictate the pace. Historically, Los Angeles has handled San Antonio well, winning four of the last five matchups. Given the Spurs’ overperformance to start the season and the Lakers’ strong home splits, this sets up as a good spot for Los Angeles. Don’t look now but every day LeBron is out, it’s becoming more and more Luka’s team. I do think the Lakers can make a run this year if LeBron can accept a lesser role in his age 40 season but for now, LA will happily ride this momentum. Expect the Lakers’ physicality and home court edge to wear down the Spurs as the game progresses.

Spurs vs Lakers Prediction: Lakers -2.5 (-110) available at time of publishing. Playable to -4

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