San Antonio Spurs vs Portland Trail Blazers Prediction, Odds and Picks for Today, 11/26/25

The Spurs enter this matchup still searching for consistency, but this spot sets up better for them than most. San Antonio continues to show flashes of real progress despite their record, particularly with Victor Wembanyama’s growing offensive command and the team’s improved spacing around him. However, Wemby will not suit up for tonight’s matchup with a calf injury. Devin Vassell and DeAaron Fox have been steadier scoring options, and the Spurs’ recent ball movement has trended upward. Their defense remains volatile, but against a Portland team that often struggles to create clean looks in the half court, San Antonio’s length and activity should be impactful.

Portland, meanwhile, has been one of the least reliable favorites in the league, entering this game just 1–6 ATS when laying points. The Blazers play hard but lack efficient scoring, ranking near the bottom in field goal percentage and assists. Injuries and inconsistent guard play continue to limit their late game execution, and their offense frequently stalls when teams force them away from transition. While Deni Avdija and Shaedon Sharpe provide stability, Portland’s overall profile doesn’t match that of a team that should be confidently favored.

Spurs vs Trail Blazers Prediction: Spurs +1.5 (-110) available at time of publishing. Playable to ML