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Best Jacksonville Jaguars vs Buffalo Bills touchdown scorer bets: Travis Etienne Jr. strikes again

Best Jacksonville Jaguars vs Buffalo Bills touchdown scorer bets: Travis Etienne Jr. strikes again

Caleb Wilfinger
Caleb WilfingerAuthor
UpdatedSep 15, 2026
Reading time3 min

Following an absolutely wild Sunday slate, Week 3 in the NFL season concludes with a pair of Monday Night Football matchups, including action in Buffalo between the Jaguars and Bills. This is one of the marquee games on the schedule, as it features a 2-0 Bills team riding high following a convincing win over the Dolphins, while the 0-2 Jaguars are in desperate need of a victory to right the ship on their season. I’ve taken a look at the anytime touchdown scorer market and have 2 picks to lock in for this fascinating AFC matchup. 

The Pickswise team was absolutely on fire with our touchdown scorer prop picks to start the 2024 season, so let’s keep the momentum going this week! Here are my Jaguars vs Bills touchdown scorer best bets for tonight, while you can also find out our NFL picks for this matchup as well as the Commanders vs Bengals game.

Read our full Jacksonville Jaguars vs Buffalo Bills predictions

Jaguars vs Bills anytime touchdown scorer pick: Travis Etienne Jr., JAX (+115)

Odds available at Caesars Sportsbook at time of publishing.

Not much has gone right for Jacksonville’s offense over the first couple of games this season, but I expect that to change in this desperation spot. Given that quarterback Trevor Lawrence has been struggling with consistently throwing the ball accurately and effectively down the field, I’m targeting Travis Etienne Jr. and the Jaguars’ ground game to be featured heavily in this matchup, particularly in the first half. As we saw against the Cardinals in Week 1, you can run on this Buffalo defense (18th in rushing yards allowed), and Etienne typically sees his workload increase on the road. The Jags starting running back already has a pair of touchdowns on the ground this season, and I expect Etienne to get plenty of work throughout the contest, so let’s take this number while it’s still at plus money.

Find out Prop Holliday’s best Jaguars vs Bills player prop bet for MNF

Jaguars vs Bills anytime touchdown scorer pick: James Cook, BUF (+115)

Odds available at FanDuel Sportsbook at time of publishing.

While I see the Jaguars having consistent success on the ground, the same can be said for the Bills on the other side of the ball. At this point, the discourse around Buffalo has largely centered around the Bills’ new offensive approach under coordinator Joe Brady, who turned the season around for Buffalo midway through the 2023 campaign. The results have been strong through the first 2 weeks of this season, particularly when it comes to the production the Bills are getting from James Cook. After losing Stefon Diggs and Gabe Davis this past offseason, the load on Cook’s shoulder in this offense got much heavier, and he’s responded to the challenge by averaging 5 yards per carry with 3 touchdowns on 30 attempts in Buffalo’s pair of wins this month. Cook looks poised to become one of the best running backs in football and his skills as a receiver out of the backfield also make him doubly a threat to find the end zone. At plus money, this price is too good to pass up for Buffalo’s offensive focal point on Monday.

Make sure you also check out our Washington Commanders vs Cincinnati Bengals best bets

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