Opening college football betting lines, odds and spreads for Week 4 of the CFB season: Can Colorado stay hot?

The Colorado Buffaloes
Photo of Ricky Dimon

Ricky Dimon


Show Bio

Since graduating from Davidson (The College That Stephen Curry Built), I have been writing about sports -- just about any and all you can think of! -- and coaching tennis in Atlanta, GA. Beyond the four major sports, I am an avid tennis fan and cover the ATP Tour on a daily basis. If I'm not busy writing, you can generally find me on a tennis court or traveling the world wherever a sporting event takes me. For Ricky Dimon media enquiries, please email
Read more about Ricky Dimon

Three weeks of the 2023 college football season are in the books. We have already witnessed a significant upset (Texas over Alabama) a crucial result in SEC positioning (Florida over Tennessee) and an undefeated sensation that is stealing headlines throughout the nation (Colorado). 

Now it’s time to turn our attention to Week 4. This slate is the best one of the season to date, headlined by Florida State vs Clemson, Ole Miss vs Alabama, Colorado vs Oregon and Ohio State vs Note Dame. The opening lines were released at most sportsbooks on Sunday, so let’s take a look at these openers and give our first impressions. 

Bet365 – the world’s #1 sportsbook – has arrived in the United States! If you sign up right now and bet just $1, you can immediately get $200 in bonus bets! Join Bet365 by clicking this link.

NCAAF Week 4 opening lines and odds

Odds available at DraftKings Sportsbook at time of publishing.  

  • Georgia State +7 (-110) vs Coastal Carolina – Thursday, September 21
  • Wisconsin -7 (-110) vs Purdue – Friday, September 22 
  • N.C. State -9 (-110) vs Virginia – Friday, September 22 
  • Boise State -7 (-110) vs San Diego State – Friday, September 22 
  • Florida State -2.5 (-110) vs Clemson – Saturday, September 23 
  • Ohio State -3 (-110) vs Notre Dame – Saturday, September 23 
  • Oklahoma -13.5 (-110) vs Cincinnati – Saturday, September 23 
  • Auburn +8 (-110) vs Texas A&M – Saturday, September 23 
  • Colorado +20.5 (-110) vs Oregon – Saturday, September 23 
  • UCLA +5.5 (-110) vs Utah – Saturday, September 23 
  • Texas Tech -4 (-110) vs West Virginia – Saturday, September 23 
  • Ole Miss +6.5 (-110) vs Alabama – Saturday, September 23 
  • Arkansas +18 (-110) vs LSU – Saturday, September 23 
  • Georgia Tech +7 (-110) vs Wake Forest – Saturday, September 23 
  • Texas -15 (-110) vs Baylor – Saturday, September 23 
  • Mississippi State +4.5 (-110) vs South Carolina – Saturday, September 23 
  • Iowa +14 (-110) vs Penn State – Saturday, September 23 
  • North Carolina -5.5 (-110) vs Pittsburgh – Saturday, September 23 

We have college football picks and predictions for all the big games this season!

DraftKings Sportsbook is currently giving new customers $200 in bonus bets when they bet $5. That’s all there is to it! Grab this amazing sign-up offer by clicking this link. 

Best early bets for NCAAF Week 4

Alabama -6.5 (-110) over Ole Miss

When you can give less than a touchdown with Alabama, it’s an opportunity that should be taken. Yes, the Crimson Tide are dealing with a quarterback issues, but I will trust head coach Nick Saban to make the right decision and give his team the best chance to win – both on Saturday and moving forward throughout the season. At some point the Tide are going to wake up from their early-season slumber; that time could be now. Ole Miss has lost 7 straight in the head-to-head series, including by 21 points the last time it visited Tuscaloosa

Colorado +20.5 (-110) over Oregon

The sportsbooks are obviously praying for the public to jump on Colorado by making this number so huge. Unfortunately for them, I think they are going to pay for it in the form of big losses. Jumping on it is exactly what I’m going to do before the number shrinks. Two-way star Travis Hunter is probably out, but he also missed much of the game against Colorado State and the Buffaloes still came back to win. It is true that Oregon is much better than Colorado State, which is why head coach Deion Sanders’ squad may not be undefeated by the end of Week 4. It should, however, do enough to cover.

Wake Forest -7 (-110) over Georgia Tech

Playing at home against one of the weakest teams in the ACC, Wake Forest should be able to win this game by multiple possessions. Sam Hartman has taken his talents to Notre Dame, but the Demon Deacons have gotten some strong quarterback play from Mitch Griffis (837 yards and 8 touchdowns, although he has been picked off 3 times). Whereas the Deacons are undefeated, the Yellow Jackets are 1-2 with a bad loss to Louisville and a blowout at the hands of Ole Miss last weekend. 

You can bet on all today’s sports at FanDuel, America’s #1 sportsbook, which has a great new customer offer where you can bet $5 and receive $200 in bonus bets plus $100 off NFL Sunday Ticket! Click here to take advantage of this awesome offer. 

By signing up you agree to our terms and privacy policy